Source: Lu CY, Zhang F, Lakoma MD, et al. Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: quasi-experimental study. BMJ.2014;348:g3596; doi:10.1136/bmj.g3596. See AAP Grand Rounds commentary by Dr. Justin Schreiber (subscription required).
PICO Question: Among adolescents and young adults, what was the effect of the FDA warning of an increased risk of suicidality with antidepressant use on suicidal behavior and antidepressant use?
Question type: HarmStudy design: Interrupted time series